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           APIs&Intermediates Chemicals of Shanghai APIs Chemical Co., Ltd 

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 Bioisosteres

  Amine:

          189321-66-2,4-Boc-2-morpholinecarboxylic acid

          168986-49-0,Methyl 4-piperidineacetate

         (R)-7-methyl-1,4-oxazepane hydrochloride

         1269533-64-3,hexahydro-2H-furo[3,4-b][1,4]oxazine

         98977-36-7,1-Boc-3-piperidone

          675-20-7,2-Piperidone

          61995-20-8,N-Cbz-3-Piperidone

          314741-40-7,(S)-3-Hydroxymethyl-piperazine-1-carboxylic acid tert-butyl ester

          278788-66-2,(R)-3-Hydroxymethyl-piperazine-1-carboxylic acid tert-butyl ester

          147739-88-6,6,7-Dihydro-5H-pyrrolo3,4-bpyridine

          4088-33-9,3-Piperidin-2-yl-propionic acid

          22264-50-2,1-Amino-cyclobutanecarboxylic acid HCl

           106825-79-0,(S)-3-Morpholinecarboxylic acid HCl

           106825-81-4,(R)-3-Morpholinecarboxylic acid HCl

           77873-76-8,3-Morpholine carboxylic acid

          151907-79-8,(1S,4R)-(−)-4-(Boc-amino)-2-cyclopentene-1-carboxylic acid

          1039738-27-6, (3R,4R)-1-benzyl-4-methylpiperidin-3-amine

           87120-72-7,4-Amino-1-Boc-piperidine

           122536-77-0,(R)- (+)-3-(tert-Butoxycarbonylamino)pyrrolidine

           122536-76-9,(S)- (+)-3-(tert-Butoxycarbonylamino)pyrrolidine

           184637-48-7,(+/-)-3-Amino-1-Boc-piperidine

           156925-22-3,(R)-2-Hydroxymethylmorpholine HCl

           218594-79-7, (S)-morpholin-3-ylmethanol hydrochloride

           199175-10-5,(3S)-3-Aminomethyl-1-Boc-pyrrolidine

           21987-29-1,4,4-Difluoropiperidine

          135632-53-0,4-(Boc-aminomethyl) piperidine

          91188-15-7,3-Boc-aminomethylazetidine

          20063-89-2,Azetidine-2-carboxylic acid

          134419-57-1,Azetidine-2-carboxylic acid methyl ester

          819078-65-4,(S)-4-Cbz-morpholine-3-carboxylic acid

          103550-76-1,2-Azetidinemethanamine

          1187929-79-8,(S)-4-Boc-3-aminomethyl-morpholine

         1187929-33-4, (R)-3-Aminomethyl-morpholine-4-carboxylic acid tert-butyl ester

          140645-53-0,2-Aminomethyl-4-Boc-morpholine

         102065-86-1,3-Aminoazetidine 2HCl

          345311-09-3|5,6,7,8-Tetrahydro-1,2,4-triazolo[4,3-a]pyrazine hydrochloride

          196613-57-7,1-Boc-hexahydro-1H-azepin-4-amine

          454451-28-6,tert-butyl azepan-4-ylcarbamate

           211053-50-8,(S)-morpholin-3-ylmethanol

           211053-49-5,(R)-morpholin-3-ylmethanol

           6291-01-6,Aminocyclobutane hydrochloride

           109105-51-3,1-Benzyl-hexahydro-4H-azepin-4-amine

           103003-01-6| 2-Hydroxymethylmorpholine

           14268-66-7| 3,4-(Methylenedioxy)aniline

           163457-23-6| 3,3-Difluoropyrrolidine HCl

           129799-08-2| 1-tert-butyl 3-methyl piperazine-1,3-dicarboxylate

            2517-04-6,Azetidine-2-carboxylic acid

           363179-66-2,3,3-difluoro-Piperidine HCl

          102679-78-7,(1R,4R)-4-aminocyclopent-2-enecarboxylic acid

           36476-78-5,3-Azetidinecarboxylic acid

           136030-00-7,Cis-(1R,2S)-1-amino-2-indanol

           126456-43-7,Cis-(1S,2R)-1-amino-2-indanol

           913702-35-9,(R)-1-(pyrrolidin-3-yl)piperidine dihydrochloride

           39093-93-1,thiomorpholine 1,1-dioxide

           210240-20-3,4-aminotetrahydro-2H-thiopyran 1,1-dioxide

           476660-77-2,4-(aminomethyl)tetrahydro-2H-thiopyran 1,1-dioxide

           148214-90-8,(3R,4R)-tert-butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate

           190792-74-6,(3S,4S)-tert-butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate

           103831-11-4,3-Aminopyrrolidine Dihydrochloride

           116183-81-4,(3R)-(-)-3-Aminopyrrolidine Dihydrochloride

           116183-83-6,(3S)-(+)-3-Aminopyrrolidine dihydrochloride

           79286-79-6,3-Aminopyrrolidine

          116183-82-5,(R)-3-Aminopyrrolidine

          128345-57-3,(S)-3-Aminopyrrolidine

           18471-40-4,1-Benzyl-3-pyrrolidinamine

           127294-77-3,3-Methylaminopiperidine Dihydrochloride

           192330-11-3,(R)-4-N-Boc-piperazine-2-carboxylic acid

           Spiro amine:

           1239589-52-6,N-(2-Aminospiro[3.3]hept-6-yl)carbamic acid tert-butyl ester

           1118786-85-8,(2-Aza-spiro[3.3]hept-6-yl)-carbamic acid tert-butyl ester

           1211586-09-2,6-Amino-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester          

           1170461-72-9,6-Amino-2-azaspiro[3.3]heptane-6-carboxylic acid HCl

 

           1147557-97-8,6-Hydroxy-2-azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester

 

           896464-16-7,tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate

 

           885272-17-3,tert-Butyl 2,6-diazaspiro[3.5]nonane-6-carboxylate

 

           1086394-57-1,2,6-Diaza-spiro[3.5]nonane-2-carboxylic acid tert-butyl ester

 

           174-78-7,2-Oxa-6-azaspiro[3.3]heptane

 

           91188-26-0,2,7-Diazaspiro[4.4]nonane, 2-methyl-,dihydrochloride

 

           241820-91-7,2-Oxa-7-azaspiro[3.5]nonane

 

          173405-78-2,3,9-Diaza-spiro5.5undecane-3-carboxylic acid tert-butyl ester

  

          236406-49-8,2-Boc-2,7-diazaspiro[4.4]nonane

 

          7010-77-7,1-oxa-3,8-diazaspiro[4.5]decane

 

        Bridged amine:

        128740-01-2,Pyrrolo[3,4-b]-1,4-oxazine,octahydro-4-methyl-,dihydrochloride

          159991-15-8,Racemic cis-tert-butyl hexahydropyrrolo[3,4-b][1,4]oxazine-6(2H)-carboxylate

          151434-64-9,(4aS,7aR)-4-benzyloctahydropyrrolo[3,4-b][1,4]oxazine

          876461-31-3,trans-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexanamine

         143062-84-4,(1R,2S)-2-Fluorocyclopropanamine4-methylbenzenesulfonate

         474925-37-6,N-BOC-3A,4,7,7A-tetrahydroisoindole

         172739-04-7,cis-2-Benzyloctahydropyrrolo3,4-cpyrrole

          250275-15-1,cis-2-Boc-hexahydropyrrolo3,4-cpyrrole

 

        833458-92-7,3-benzyl-3-azabicyclo[3.2.1]octan-6-one

 

          1260595-26-3,(3aS,7aR)-tert-butyl 5-oxooctahydro-1H-indole-1-carboxylate

 

          143268-07-9,(3aR,7aS)-tert-butyl 5-oxooctahydro-1H-indole-1-carboxylate

 

           351370-98-4,2-Benzyl-octahydro-pyrrolo3,4-cpyridine 

 

           885959-24-0,2-Methyl-octahydro-pyrrolo3,4-cpyridine

 

           351370-99-5,5-Boc-octahydro-pyrrolo3,4-cpyridine

 

          159877-36-8,1-Boc-octahydro-pyrrolo[3,4-b]pyridine

 

           871792-60-8,6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine

 

           147740-02-1,6,7-Dihydro-5H-pyrrolo[3,4-b]pyridine dihydrochloride

 

          1181643-74-2, (hexahydro-1H-pyrrolo[2,1-c][1,4]oxazin-3-yl)methanamine

 

          1143524-12-2,((3R,8aR)-hexahydro-1H-pyrrolo[2,1-c][1,4]oxazin-3-yl)methanamine

 

          1143524-10-0,((3S,8aR)-hexahydro-1H-pyrrolo[2,1-c][1,4]oxazin-3-yl)methanamine

 

          1143524-08-6,((3S,8aS)-hexahydro-1H-pyrrolo[2,1-c][1,4]oxazin-3-yl)methanamine

 

          1143524-06-4,((3R,8aS)-hexahydro-1H-pyrrolo[2,1-c][1,4]oxazin-3-yl)methanamine

 

          86732-28-7,2-Methyl-octahydro-pyrrolo[3,4-c]pyrrole     

 

          203661-67-0,tert-butyl 5-hydroxyhexahydro-1H-isoindole-2(3H)-carboxylate

 

          1-(4-ethylpyrrolidin-3-yl)propan-2-one

 

          tert-butyl 3-ethyl-4-(2-oxopropyl)pyrrolidine-1-carboxylate

 

          1187385-53-0, hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one hydrochloride

 

          151763-89-2,(R)-hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one

 

          151763-88-1,(S)-hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one

 

          117810-52-3,Tetrahydropyrrolo[1,2-a]pyrazin-6(1H,2H,7H)-one

 

          1303975-09-8,(S)-hexahydropyrrolo[1,2-a]pyrazin-4(1H)-one hydrochloride

 

          1303974-99-3,(R)-hexahydropyrrolo[1,2-a]pyrazin-4(1H)-one hydrochloride

 

          1000577-63-8,hexahydropyrrolo[1,2-a]pyrazin-4(1H)-one

 

          929047-07-4,(R)-hexahydropyrrolo[1,2-a]pyrazin-4(1H)-one

 

          124072-84-0,(S)-hexahydropyrrolo[1,2-a]pyrazin-4(1H)-one

 

          (1R,6S)-methyl 10-aminobicyclo[4.3.1]decane-8-carboxylate

 

          54745-74-3,(1R,5S)-8-oxa-3-aza-bicyclo[3.2.1]octane

 

          141449-85-6,tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

 

          145012-51-7,((7R,9aS)-octahydro-1H-pyrido[1,2-a]pyrazin-7-yl)methanol

 

          145012-50-6,((7S,9aS)-octahydro-1H-pyrido[1,2-a]pyrazin-7-yl)methanol

 

          433734-91-9,((7R,9aR)-octahydro-1H-pyrido[1,2-a]pyrazin-7-yl)methanol

 

          1097253-02-5,(octahydro-1H-pyrido[1,2-a]pyrazin-7-yl)methanol

 

          179089-68-0,((7R,9aS)-octahydro-1H-pyrido[1,2-a]pyrazin-7-yl)methanol dihydrochloride

 

          247091-98-1,((7S,9aS)-octahydro-1H-pyrido[1,2-a]pyrazin-7-yl)methanol dihydrochloride

 

          156856-52-9,(7R,9aS)-tert-butyl 7-(hydroxymethyl)hexahydro-1H-pyrido[1,2-a]pyrazine-2(6H)-carboxylate

 

          156856-50-7,(7S,9aS)-tert-butyl 7-(hydroxymethyl)hexahydro-1H-pyrido[1,2-a]pyrazine-2(6H)-carboxylate

 

          14805-29-9,(3aR,4S,7R,7aS)-hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione

 

          185693-12-3,tert-butyl octahydrocyclopenta[c]pyrrol-4-ylcarbamate

 

 

 

 

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