Ring-closing metathesis (RCM) of dienes is one
of the most important methodologies now in use
for the assembly of cyclic organic compounds.
RCM represents a key step in many synthetic
sequences [Chem.Rev.]. Our company
can produce Ru-based catalysts such as
Grubbs 2nd and
Catalyst..., and can large-scale
produce in 2010. We also have developed our own
catalysts which are appling for patent. In the
same time, we have applied these catalysts in
the large scale production of macrocyclic
the inhibitor of HCV
BILN-2061 for example:
Boehringer-Ingelheim’s 2006 first disclosure of
a large-scale RCM approach to the HCV protease
inhibitor BILN-2061 provides an interesting case
study for those contemplating a large-scale
metathesis process. And we can close this
macrocyclic at ROOM temperature in DCM.
Large-scale RCM was also used in
GlaxoSmithKline’s 2009 synthesis of cathepsin K
of these examples show that it is powerful using
RCM in the process of macrocyclic drugs. We are
forward to cooperating with you!
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Not for human use. We do not sell to patients.