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       APIs Chemical process research & development team helps our customers manufacture their drug candidates more efficiently. Our Process philosophy: Convenient route; Simple operation; Avoid dangerous reagents; Fewest solvents; Safety; High yield; Recrystallization; Optimization catalytic reaction; Minimize waste; Minimize impurity; Atom economy.


      A Case as follows:


      ABT888(CAS#912444-00-9) is a potential anti-cancer drug acting as a PARP inhibitor, it inhibits both PARP1 and PARP2, the synthesis route of medicinal chemistry is reported by ABBOTT in US2006/229289
:


 

 

Steps

Chirality

Work-up

Overall Yield

Product

Initial Route

9

Chiral resolution

Column Chromatography

Low

White solid, Purity:98%min, ee:97%min

Optimized Process

8

Cheap Chiral source

Recrystallization

High

White crystalline, Purity:98%min, ee:98%min

       In this case, we apply our Process philosophy: Convenient route; Simple operation; Recrystallization; Atom economy. Now, we can produce this compound in large scale.

       Hope we can cooperate with you! We believe that our cooperation will make the future more beautiful!!!

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